Pathology: epithelioid haemangioma

Multi-lobulated; epithelioid cells with vasoformative pattern

Eosinophilic cytoplasm with occasional clear vacuoles

Ovoid nuclei with prominent nucleoli and mild pleomorphism; mitotic activity 

IHC: ERG

RNA-seq: negative

Lobulated; loose sheets of epithelioid-spindle cells 

Eosinophilic cytoplasm with occasional clear vacuoles, some with erythrocytes

Ovoid nuclei with prominent nucleoli and mild pleomorphism; inconspicuous mitotic activity

IHC: ERG

RNA-seq: GATA6::FOXO1 gene fusion

PMID: 33318580

Multi-lobulated; nests of epithelioid cells

Eosinophilic cytoplasm with occasional clear vacuoles, some with amorphous debris

Ovoid nuclei with prominent nucleoli and mild pleomorphism; inconspicuous mitotic activity

IHC: ERG

RNA-seq: GATA6::FOXO1 gene fusion

PMID: 33318580

Lobulated; epithelioid cells with vasoformative pattern

Eosinophilic cytoplasm with occasional clear vacuoles, some with amorphous debris

Ovoid nuclei with prominent nucleoli and mild pleomorphism; inconspicuous mitotic activity

RNA-seq: negative

Lobulated; epithelioid cells with nested and vasoformative patterns 

Eosinophilic cytoplasm with occasional clear vacuoles, some with erythrocytes

Ovoid nuclei with prominent nucleoli and mild pleomorphism; inconspicuous mitotic activity

IHC: ERG

RNA-seq: negative

Epithelioid-spindle cells with nested and vasoformative patterns

Eosinophilic cytoplasm with occasional clear vacuoles, some with amorphous debris

Ovoid nuclei with prominent nucleoli, vesicular chromatin and mild pleomorphism; occasional mitotic activity

IHC: ERG

RNA-seq: negative

Epithelioid-spindle cells with nested and vasoformative patterns

Eosinophilic cytoplasm with occasional clear vacuoles, some with amorphous debris

Ovoid nuclei with prominent nucleoli, vesicular chromatin and mild pleomorphism; inconspicuous mitotic activity

IHC: CD31, CD34, ERG

RNA-seq: negative