Secondary chondrosarcoma
Chondrosarcoma
Chondrosarcoma
Prior history of exostosis
Lobulated; mildly cellular lobules of polygonal cells
Pale eosinophilic cytoplasm
Round-ovoid hyperchromatic nuclei with mild pleomorphim; inconspicuous mitotic activity
Abundant hyaline cartilage matrix
DNA-seq: EXT2 mutation
Chondrosarcoma
Chondrosarcoma
Prior history of synovial chondromatosis
Infiltrative; moderately cellular lobules of stellate-epithelioid cells
Pale amphophilic cytoplasm
Ovoid hyperchromatic nuclei with moderate pleomorphism; rare mitotic activity
Abundant hyaline cartilage matrix; focal necrosis
PMID: 1985712