Gastrointestinal pathology

Angiomyolipoma

• IHC: HMB45, Melan-A

Haemangioendothelioma, epithelioid

• IHC: ERG

• RNA-seq: WWTR1::CAMTA1 gene fusion

Leiomyosarcoma

• IHC: H-caldesmon

Clear cell sarcoma-like tumour of the gastrointestinal tract

• RNA-seq: EWSR1-CREB1 gene fusion

Liposarcoma, dedifferentiated

• IHC: MDM2, CDK4

• FISH: MDM2 gene amplification

Desmoid fibromatosis

Epithelial-stromal polyp, sessile serrated polyp (perineurioma)

• DNA-seq: BRAF; c.1799T >A (p.Val600Glu)

• PMID: 15958849, 33313671

Gastroblastoma

• RNA-seq: MALAT1-GLI1 gene fusion

• PMID: 28731043

Kaposi sarcoma

• IHC: ERG, HHV8

Leiomyoma

• IHC: H-caldesmon, CD34, CD117, DOG1

• DNA-seq: negative 

NB: colonization and hyperplasia [of leiomyoma] by non-neoplastic interstitial cells of Cajal. PMID: 24145645

Leiomyosarcoma

• IHC: smooth muscle actin, H-caldesmon

Leiomyosarcoma

• IHC: H-caldesmon

Leiomyosarcoma

• IHC: H-caldesmon

Lipoma

• FISH: MDM2 non-amplified

Plexiform fibromyxoma

• IHC: CD56, smooth muscle actin 

• RNA-seq: MALAT1-GLI1 gene fusion

• PMID: 19675452, 27101025 

Schwannoma

• IHC: S100, SOX10

Schwannoma

• IHC: S100, SOX10

Sclerosing epithelioid fibrosarcoma (primary)

• IHC: MUC4

• RNA-seq: FUS-CREB3L2  gene fusion 

Synovial sarcoma (primary)

• IHC: keratin (AE1/AE3)

• RNA-seq: SS18-SSX1 gene fusion 

NUTM1-rearranged neoplasm

• IHC: Pankeratin, EMA, p63

• RNA-seq: MXI1::NUTM1 gene fusion