Pathology: malignant melanotic nerve sheath tumour
Malignant melanotic nerve sheath tumour
Malignant melanotic nerve sheath tumour
Lobulated; spindle-epithelioid cells in short fascicles
Eosinophilic cytoplasm, with focal pigmentation
Plump ovoid nuclei, with mild pleomorphism and occasional pseudonuclear inclusions; inconspicuous mitotic activity
Prominent psammomatous calcification
IHC: CD34, S100, SOX10
Malignant melanotic nerve sheath tumour
Malignant melanotic nerve sheath tumour
Lobulated; spindle-epithelioid cells in short fascicles
Eosinophilic cytoplasm with obscuring pigmentation
Plump ovoid nuclei, with mild pleomorphism and macronucleoli; inconspicuous mitotic activity
Rare psammomatous calcification
IHC: S100, HMB45, Melan-A