Pathology: infantile fibrosarcoma
Infantile fibrosarcoma
Infantile fibrosarcoma
Sheets-fascicles of round-polygonal cells
Pale and eosinophilic cytoplasm
Round nuclei with small nucleoli and mild pleomorphism; inconspicuous mitotic activity
Dilated-ectatic blood vessels
Inflammatory infiltrate with lymphocytes and eosinophils
IHC: smooth muscle actin
RNA-seq: ETV6::NTRK3 gene fusion