Thoracic pathology

Angiosarcoma

• IHC: ERG, D2-40, MYC

Angiosarcoma

Hibernoma

• FISH: MDM2 non-amplified

Hibernoma

• FISH: MDM2 non-amplified

Intimal sarcoma

• IHC: MDM2, CDK4

• FISH: MDM2 amplified

Intimal sarcoma

• IHC: MDM2, CDK4

• FISH: MDM2 amplified

Synovial sarcoma, poorly differentiated

• RNA-seq: SS18::SSX1 gene fusion 

Inflammatory myofibroblastic tumour

• IHC: ALK1

• RNA-seq: EML4::ALK gene fusion

Lymphangioleiomyomatosis

• IHC: D2-40, HMB45, SMA

• RNA-seq: TSC2 p.Q166 SNV identified

Primary pulmonary myxoid sarcoma

• IHC: ALK1

• RNA-seq: EWSR1::CREB1 gene fusion

• IHC: ALK

• PMID: 21997693

Primary pulmonary myxoid sarcoma

• RT-PCR: EWSR1::CREB1 gene fusion

• PMID: 21997693

Solitary fibrous tumour, primary

• IHC: CD34, STAT6

• RNA-seq: NAB2::STAT6 gene fusion

Solitary fibrous tumour, primary

• IHC: CD34, STAT6

• RNA-seq: NAB2::STAT6 gene fusion

Solitary fibrous tumour, metastatic

• IHC: STAT6

• RNA-seq: NAB2::STAT6 gene fusion

Synovial sarcoma

• IHC: keratin (AE1/AE3)

• RNA-seq: SS18::SSX2 gene fusion

Undifferentiated pleomorphic sarcoma, metastatic

• IHC: smooth muscle actin

Solitary fibrous tumour

• IHC: CD34, STAT6

• RNA-seq: NAB2::STAT6 gene fusion

Liposarcoma, dedifferentiated

• IHC: MDM2, CDK4

• FISH: MDM2 amplified

Mesothelioma

• RNA-seq:  EWSR1::ATF1 gene fusion

Mesothelioma

• RNA-seq:  EWSR1::ATF1 gene fusion