Pathology: deep (aggressive) angiomyxoma
Deep (aggressive) angiomyxoma
Hypocellular; spindle-stellate cells in loose fascicles
Eosinophilic cytoplasm with delicate tapering processes
Monomorphic ovoid nuclei; inconspicuous mitotic activity
Abundant myxoid stroma; wispy collagen fibres, particularly around vessels; ectatic small-medium vessels with occasional thickened walls
Deep (aggressive) angiomyxoma
Mild cellularity; spindle-stellate cells in loose fascicles
Eosinophilic cytoplasm with delicate tapering processes
Monomorphic ovoid nuclei; inconspicuous mitotic activity
Abundant myxoid stroma; ectatic medium vessels; occasional "myoid bundles" surrounding vessels
IHC: desmin, estrogen receptor
Deep (aggressive) angiomyxoma
Hypocellular; spindle-stellate cells in loose fascicles
Eosinophilic cytoplasm with delicate tapering processes
Monomorphic ovoid nuclei; inconspicuous mitotic activity
Abundant myxoid stroma; ectatic small-medium vessels; interspersed "myoid bundles", particularly surrounding vessels; interspersed mature adipocytes