Pathology: EWSR1::CREM mesenchymal tumour

Centred within the dermis; nests and fascicles of epithelioid cells
Amphophilic cytoplasm
Ovoid-round nuclei with prominent nucleoli; mild pleomorphism; inconspicuous mitotic activity
Collagenous stroma; pseudoepitheliomatous hyperplasia
IHC: HMB45, S100, SOX10
RNA-seq: EWSR1::CREM gene fusion
PMID: 28009602

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Soft Tissue Tumours

Tumours of Uncertain Differentiation