Pathology: simple bone cyst
Simple bone cyst
Cyst with collagenous wall
Spindle-stellate cells with pale amphophilic cytoplasm; monomorphic ovoid nuclei and inconspicuous mitotic activity with abundant interspersed collagenous stroma
Sheets of foamy histiocytes; osteoclast-type giant cells; cholesterol clefts with foreign body giant cells; siderophages and haemosiderin deposition; sheets of hyalinized collagen
Most of these tumours are characterized by EWSR1/FUS-NFATC2 gene fusions (PMID: 32991339)
Simple bone cyst
Cyst with collagenous wall
Spindle-stellate cells with pale amphophilic cytoplasm; monomorphic ovoid nuclei and inconspicuous mitotic activity with abundant interspersed collagenous stroma
Siderophages and haemosiderin deposition; sheets of hyalinized collagen
Most of these tumours are characterized by EWSR1/FUS-NFATC2 gene fusions (PMID: 32991339)