Pathology: myxofibrosarcoma

Myxofibrosarcoma

  • Lobulated; hypocellular; spindle cells with vague fascicular pattern

  • Eosinophilic cytoplasm with long tapering processes

  • Ovoid nuclei with mild-moderate pleomorphism; inconspicuous mitotic activity

  • Abundant myxoid stroma, with thin fibrous septa; delicate curvilinear vasculature

  • Occasional pseudolipoblasts

Myxofibrosarcoma

  • Lobulated; hypocellular; spindle cells with vague fascicular pattern

  • Eosinophilic cytoplasm with long tapering processes

  • Ovoid nuclei with mild-moderate pleomorphism; inconspicuous mitotic activity

  • Abundant myxoid stroma, with thin fibrous septa; delicate curvilinear vasculature

  • Frequent pseudolipoblasts

Myxofibrosarcoma

  • Lobulated; variable cellularity; spindle cells with vague fascicular pattern

  • Amphophilic cytoplasm with long tapering processes

  • Ovoid nuclei with moderate-marked pleomorphism, and occasional multinucleation; conspicuous mitotic activity

  • Prominent myxoid stroma with thin fibrous septa; delicate curvilinear vasculature; pseudolipoblasts

Myxofibrosarcoma

  • Lobulated; variable cellularity; spindle cells with vague fascicular pattern

  • Eosinophilic cytoplasm with long tapering processes

  • Ovoid nuclei with moderate-marked pleomorphism, and occasional multinucleation; conspicuous mitotic activity

  • Areas of myxoid stroma, with thin fibrous septa; delicate curvilinear vasculature

Myxofibrosarcoma

  • Lobulated; cellular; spindle cells with vague fascicular pattern

  • Eosinophilic cytoplasm with long tapering processes

  • Ovoid nuclei with mild-moderatepleomorphism; conspicuous mitotic activity

  • Rare foci with myxoid stroma and delicate curvilinear vessels

Myxofibrosarcoma, epithelioid

  • Lobulated; variable cellularity; spindle-epithelioid cells in fascicles and clusters

  • Amphophilic cytoplasm

  • Round-ovoid nuclei with prominent nucleoli, moderate pleomorphism; conspicuous mitotic activity

  • Areas of myxoid stroma; delicate curvilinear vasculature

  • Occasional pseudolipoblasts

  • Focal necrosis

Myxofibrosarcoma, epithelioid

  • Variable cellularity; spindle-epithelioid cells in fascicles and clusters

  • Amphophilic cytoplasm

  • Round-ovoid nuclei with mild-moderate pleomorphism; mitotic activity

  • Abundant myxoid stroma; delicate curvilinear vasculature

  • Occasional pseudolipoblasts