Pathology: leiomyoma

Leiomyoma, fumarate hydratase-deficient

Multinodular; fascicles of spindle cells
Abundant eosinophilic cytoplasm
Ovoid nuclei and small nucleoli with occasional perinucleolar halo; inconspicuous mitotic activity
IHC: H-caldesmon, fumarate hydratase
DNA-seq: FH p.S334R SNV

Leiomyoma

Interwoven fascicles of spindle cells
Bright eosinophilic cytoplasm with occasional perinuclear vacuoles
Ovoid and elongated nuclei with rounded ends; inconspicuous mitotic activity
IHC: H-caldesmon

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