Pathology: intimal sarcoma

Spindle-polygonal cells with patternless distribution

Pale aeosinophilic cytoplasm

Round-ovoid nuclei with prominent nucleoli and moderate pleomorphism; mitotic activity 

Collagenous stroma; inflammatory infiltrate; necrosis

IHC: MDM2, CDK4

FISH: polysomy

Spindle-polygonal cells with patternless distribution

Pale aeosinophilic cytoplasm

Round-ovoid nuclei with prominent nucleoli and moderate pleomorphism; mitotic activity 

Necrosis

IHC: MDM2, CDK4

FISH: MDM2 amplified

Polygonal cells with patternless distribution

Pale amphophilic cytoplasm

Round-ovoid nuclei with prominent nucleoli and marked pleomorphism; mitotic activity 

Collagenous stroma; prominent ectatic vessels lined by atypical cuboidal endothelial cells; mild chronic inflammation, and eosinophils; necrosis

IHC: MDM2, CDK4

FISH: MDM2 amplified

Sheets and fascicles of spindle-epithelioid cells

Pale amphophilic cytoplasm 

Round-ovoid nuclei with irregular membranes, small nucleoli, moderate pleomorphism and occasional multinucleation; mitotic activity 

Myxoid-collagenous stroma; necrosis

IHC: MDM2

FISH: MDM2 amplified

Spindle-stellate cells with storiform pattern

Pale amphophilic cytoplasm with delicate processes

Ovoid nuclei with small nucleoli and mild pleomorphism; inconspicuous mitotic activity 

Focal collagenous stroma; mild chronic inflammation

FISH: MDM2 amplified

Spindle-stellate cells with loose fascicular-storiform pattern

Pale eosinophilic cytoplasm with delicate processes

Ovoid nuclei with small nucleoli and mild pleomorphism; inconspicuous mitotic activity 

Loose myxoid-collagenous stroma; mild chronic inflammation; necrosis

IHC: MDM2

FISH: MDM2 amplified