Pathology: haemangioma

Capillary-sized vascular channels with anastomosing sinusoidal pattern

Eosinophilic cytoplasm with occasional hyaline globules

Round-ovoid nuclei with occasional "hobnailing" and mild atypia; inconspicuous mitotic activity

Occasional fibrin thrombi

DNA-seq: GNAQ exon 5 mutation; c.627A>T (p.Gln209His)

Vessels with prominent adipocytic background

Vessels of varying caliber and mural thickness

Endothelial cells are attenuated with eosinophilic cytoplasm, and bland nuclei

Fibrosis; chronic inflammation; atrophic / regenerative skeletal muscle

Lobulated

Large central feeding vessels extend peripherally to small lobules of capillary-sized vessels

Pale amphophilic cytoplasm

Ovoid hyperchromatic nuclei with mild atypia; occasional mitotic activity

Overlying epithelial ulceration 

Lobulated

Central feeding vessels extend peripherally to small lobules of capillary-sized vessels

Pale amphophilic cytoplasm

Ovoid nuclei with mild atypia; rare mitotic activity

Centred within vessel lumen

IHC: ERG, CD31

 PMID: 575269 

Lobulated

Central feeding vessels extend peripherally to small lobules of capillary-sized vessels

Pale amphophilic cytoplasm

Ovoid nuclei with mild atypia; rare mitotic activity

Centred within vessel lumen

 PMID: 575269 

Lobulated; congested ectatic and anastomosing vascular spaces lined by endothelial monolayer

Eosinophilic cytoplasm

Monomorphic ovoid hyperchromatic nuclei; inconspicuous mitotic activity 

Centrally prominent papillary endothelial hyperplasia

PMID: 1746680

Lobulated; fascicles of spindle cells admixed with vasoformative areas ranging from small and solid clusters to patulous thin walled channels

Eosinophilic cytoplasm, occasional vacuolation and rare hyaline inclusions

Ovoid nuclei with minimal pleomorphism; inconspicuous mitotic activity

Circumscribed

Admixture of capillary-like and cavernous vascular channels

Endothelial cells are attenuated with eosinophilic cytoplasm

Monomorphic ovoid nuclei; inconspicuous mitotic activity

Congested and dilated vessels; focal myxoid stroma