Pathology: chondroid lipoma
Chondroid lipoma
Lobulated with thin fibrous capsule; sheets of small polygonal cells
Eosinophilic and variably vacuolated, cytoplasm
Round, scalloped nuclei with mild atypia; inconspicuous mitotic activity
Interspersed there are mature adipocytes with abundant clear cytoplasm and small peripheral nuclei
Chondroid lipoma
Lobulated neoplasm bound by thin fibrous capsule
Sheets of small polygonal cells with eosinophilic, and variably vacuolated, cytoplasm
Round, scalloped nuclei with mild atypia; inconspicuous mitotic activity
Interspersed there are mature adipocytes with abundant clear cytoplasm and small peripheral nuclei
RNA-seq: C11orf95::MKL2 gene fusion
Chondroid lipoma
Lobulated neoplasm; sheets of polygonal cells
Eosinophilic and variably vacuolated cytoplasm
Round, scalloped nuclei with mild atypia; inconspicuous mitotic activity
Interspersed bands of hyaline stroma; nests and sheets of mature adipocytes with abundant clear cytoplasm and small peripheral nuclei